In a dystopia riddled with corruption and cybernetic implants, a talented but reckless street kid strives to become a mercenary outlaw — an edgerunner.

In the year 2024, the world has collapsed. Grotesque monsters lurk amongst the ruins of Japan, while remaining people scrape together what they can to survive. Kiruko, an odd-job girl in Nakano, accepts a mysterious woman's dying wish to take a boy named Maru to a place called Heaven. Maru is convinced that there will be a boy there who looks exactly like him.

Humans that have been physically altered and turned into dangerous weapons are known as the Extended. Juuzou Inui awakens as one of these weapons — with amnesia. But his job as an agent investigating the Extended leads to a mysterious child with Extended ties showing up at his office. Now Inui must keep the child away from street gangs and the megacorporation Berühren, and it won't be easy.

MegaTokyo 2027: Relentless technological development has resulted in the creation of Boomers. These are artificially intelligent androids with the potential to free mankind from physical labor; but anything that can be used can also be misused.

Humanity has found a way to achieve infinite energy by using coils to draw it from the fourth plane: dimension "W". With the production of coils having been monopolized by the New Tesla energy company, freelance collectors are hired to find and remove any illegal, unofficial coils. This is the story of collector Kyōma, who also happens to have a huge hatred towards coils. During one of his missions he stumbles upon a female android that perceives herself as being human, leading the two to enter an unlikely partnership.

When Shibuya time-warps to 2388, high schooler Daisuke and his friends are conscripted by AHRV agent Milo to fight the hostile cyborg race, revisions.

Located in the center of a remote island, the Abyss is the last unexplored region, a huge and treacherous fathomless hole inhabited by strange creatures where only the bravest adventurers descend in search of ancient relics. In the upper levels of the Abyss, Riko, a girl who dreams of becoming an explorer, stumbles upon a mysterious little boy.

In the year 2045, cybernetic mercenary Motoko Kusanagi returns to Section 9 to face a dangerous new threat: the posthumans.

Many centuries ago, man's Armageddon gave birth to the vampires' wrath. As man and immortal clash, a reality-shattering threat looms. Hope resides solely in a new breed of hunter operating under the Vatican's authority. The true battle between holiness and evil has begun.

Spurred by the flame raging in his heart, the Black Swordsman Guts continues his seemingly endless quest for revenge. Standing in his path are heinous outlaws, delusional evil spirits, and a devout child of god. Even as it chips away at his life, Guts continues to fight his enemies, who wield repulsive and inhumane power, with nary but his body and sword—his strength as a human.

Denizens of Lux have come to call it "The City" and treat it as a sentient force. Three factions vie for control of the city: the Organo, a strictly professional conglomerate with ties to the criminal underworld in the prosthetics business; the Union, a fanatical populist group interfering with Organo's affairs; and Racan, a marauding group of Texhnolyzed youths.

An overworked 24-year-old finally decides to live a little and create a bucket list, when a zombie outbreak hits the country.

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore.

Amnesiac Caiman seeks to undo his lizard head curse by killing the sorcerer responsible, with his friend Nikaido's help. In the Hole, that's a threat.

The story follows Motoko Kusanagi, a highly skilled member of the military, whom upon meeting Daisuke Aramaki, a current chief of the Public Security Section 9, in less than desirable conditions struggles to clear her name whilst forming her own independent team with the highest priority under the sponsorship and guidance of the chief Aramaki himself.

Accused of murder and thrown into the Pit, a young orphan joins a group of monster fighters with special powers to uncover the truth and seek vengeance.

Los Angeles 2032. A young woman wakes up with no memories, and possessing deadly skills. The only clues to her mystery are a locked data device and a tattoo of a black lotus. Putting together the pieces, she must hunt down the people responsible for her brutal and bloody past to find the truth of her lost identity.

The year is 2062. Earth has been left in ruin after the failure of a labor automation project when the AI called Artemis waged war against humanity. A girl, Empress, awakens in a research lab. As one of the three surviving guardians, she must destroy the Orbital Elevator before Artemis can complete its construction. Failure will result in a machine army overrunning Earth.

In the 2030s Earth has been overrun by the Blue, which are mutated insect-like creatures that kill and harvest humans for food. Most of the surviving human race has moved to Second Earth, a huge spaceship that orbits the planet. Yuji and Marlene must work together to reach Second Earth and fight against the Blue.

The Diclonius, a mutated homo sapien that is said to be selected by God and will eventually become the destruction of mankind, possesses two horns in their heads, and has a "sixth sense" which gives it telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murder most of the guards in the laboratory, only to get shot in the head as she makes her escape. She survives and manages to drift along to a beach, where two teenagers named Kouta and Yuka discovers her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the evil "Lucy" is not dead just yet...