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On the outside, Helen has it all – a loving family and a successful career – but when her suppressed mental illness resurfaces, the world crumbles around her. Crippled by depression, Helen finds solace through her friendship with Mathilda, a kindred spirit struggling with bipolar disorder.

When a man is diagnosed with terminal cancer, he takes custody of his misanthropic teenage son, for whom quality time means getting high, engaging in small-time prostitution, and avoiding his father.

A man's nervous breakdown causes him to leave his wife and live in his attic for several months.

"Boxcar" Bertha Thompson, a transient woman in Arkansas during the violence-filled Depression of the early '30s, meets up with rabble-rousing union man "Big" Bill Shelly and the two team up to fight the corrupt railroad establishment.

An 11-year-old girl watches her father come down with a crippling depression. Over one summer, she learns answers to several mysteries and comes to terms with love and loss.

George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.

Facing eviction in a city her family can no longer afford, a woman plunges into a desperate and increasingly dangerous all-night search to raise $25,000.

A Pulitzer-winning writer grapples with being a widower and father after a mental breakdown, while, 27 years later, his grown daughter struggles to forge connections of her own.

Marion is a woman who has learned to shield herself from her emotions. She rents an apartment to work undisturbed on her new book, but by some acoustic anomaly she can hear all that is said in the next apartment in which a psychiatrist holds his office. When she hears a young woman tell that she finds it harder and harder to bear her life, Marion starts to reflect on her own life. After a series of events she comes to understand how her unemotional attitude towards the people around her affected them and herself.

Famed but tormented artist Vincent van Gogh spends his final years in Arles, France, painting masterworks of the natural world that surrounds him.

A unique friendship develops when a little girl and her dying mother inherit a cook - Mr. Church. What begins as an arrangement that should only last six months, instead spans fifteen years.

A boozy lowlife tries to bury the truth about his crazy stepson's suspicious death, but a nosy newspaper columnist and the young man's mother complicate matters.

A Marine veteran working as a school janitor tries to mend his relationship with his son after a divorce. When his son is killed by a police officer found innocent without standing trial, he takes matters into his own hands.

In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.

Julie is a new mom and children's book author, who escapes into the bright Crayola-colored world of her creation in order to leave behind the darkness caused by her post-partum depression.

Deckard Shaw seeks revenge against Dominic Toretto and his family for his comatose brother.

Rory is an ambitious entrepreneur who brings his American wife and kids to his native country, England, to explore new business opportunities. After abandoning the sanctuary of their safe American suburban surroundings, the family is plunged into the despair of an archaic '80s Britain and their unaffordable new life in an English manor house threatens to destroy the family.

An aimless young man who is scalping tickets, gambling and drinking, agrees to coach a Little League team from the Cabrini Green housing project in Chicago as a condition of getting a loan from a friend.

Calvin Campbell is a former professional baseball player sent to an early retirement due to his panic attacks at the plate. Even though he had all the talent for the big leagues, he struggles with the curveballs life has thrown him. Today, he mindlessly sleepwalks through his days and the challenge of raising his teenager daughter. His life is in a slow downward spiral when it is suddenly awakened and invigorated by the most unlikely person – Produce, a young-man with Down syndrome who works at the local grocery store.

A middle aged carpenter, who requires state welfare after injuring himself, is joined by a single mother in a similar scenario.