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Agnes and her two sisters struggle through a day in a home overrun by gamblers, thieves, and johns.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

A recent widow invites her husband's troubled best friend to live with her and her two children. As he gradually turns his life around, he helps the family cope and confront their loss.

When 13-year-old Tracy befriends Evie, the most popular girl in school, her life is turned upside down as Evie introduces her to a world of sex, drugs, and money. But it isn’t long before Tracy’s new lifestyle begins to take a heavy toll on her and her family.

In the late 1990s, up-and-coming mixed martial artist Mark Kerr aspires to become the greatest fighter in the world. However, he must also battle his opioid dependence and a volatile relationship with his girlfriend Dawn.

A logger defends his family from a group of dangerous drug runners.

After serving six years for killing his schoolmate, a young man learns that someone is out for revenge.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.

The eldest son of a ruthlessly tough MMA champion must fight his way out of the abusive cycle his father has continued.

A lawyer who is a drug addict fights a medical-supplies corporation in court while battling his personal demons.

In the streets of East Los Angeles, Manny is a formidable drug dealer. Impressed by his extravagant lifestyle and prowess, his young son, Kilo, yearns to follow in his footsteps. Kilo resolves to learn how to prosper in the drug world, and his new life as a dealer begins. In a world where a man wants everything, he may end up with nothing.

When seventeen-year-old Hannah stumbles upon a website about Thinspiration--an online community devoted to anorexia as a life choice--she becomes an obsessive follower of the site founder, ButterflyAna. By the time Hannah's family realizes what is happening and get Hannah the help she needs, the disease has fully taken hold and Hannah is refusing to eat. Will this family be able to exorcise the demon of anorexia from their lives?

A voluptuous black woman takes a job as a high-class prostitute in order to get revenge on the mobsters who murdered her boyfriend.

Fred Daly returns to Ireland with nowhere to live but his car. Then dope-smoking 21-year-old Cathal parks beside him, and brightens up his lonely world. Encouraged by Cathal, Fred meets attractive music teacher Jules. Growing closer, these three outsiders are set on a course that will change their lives forever.

In the hope of a big score, two junkie couples team up to commit various drug robberies which go disastrously wrong, leading to dissent, violence, and murder.

A high school basketball player’s life turns upside down after free-falling into the harrowing world of drug addiction.