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Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.

Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.

When reporter Jean Craddock interviews Bad Blake—an alcoholic, seen-better-days country music legend—they connect, and the hard-living crooner sees a possible saving grace in a life with Jean and her young son.

Thane Furrows, an extremely cynical but unintentionally hilarious children's book writer, wakes up one morning, and, since pretty much everyone and everything annoys him, begins another day of complaining to himself. However, the day proves to be much different than normal when Thane begins to recieve strange phone calls, letters, and voices in his head, all indicating that something will happen at 8 o'clock. As the day goes on, Thane rants and raves about the things that annoy him, as the clock slowly ticks closer and closer to his destiny.

Harold Crick is a lonely IRS agent whose mundane existence is transformed when he hears a mysterious voice narrating his life.

On the brink of turning 30, a promising theater composer navigates love, friendship and the pressure to create something great before time runs out.

A struggling young writer finds his life and work dominated by his unfaithful wife and his radical feminist mother, whose best-selling manifesto turns her into a cultural icon.

Carol White, a Los Angeles housewife in the late 1980s, comes down with a debilitating illness with no clear diagnosis.

Vada Sultenfuss is obsessed with death. Her mother is dead, and her father runs a funeral parlor. She is also in love with her English teacher, and joins a poetry class over the summer just to impress him. Thomas J., her best friend, is "allergic to everything", and sticks with Vada despite her hangups. When Vada's father hires Shelly, and begins to fall for her, things take a turn to the worse...

The Words follows young writer Rory Jansen who finally achieves long sought after literary success after publishing the next great American novel. There's only one catch - he didn't write it. As the past comes back to haunt him and his literary star continues to rise, Jansen is forced to confront the steep price that must be paid for stealing another man's work, and for placing ambition and success above life's most fundamental three words.

Dallas, a burdened but headstrong dancer, is determined to get into the best dance school in the country—her late mother’s alma mater. However, that dream is suddenly derailed when the cheeky yet secretly grieving football star, Drayton, crashes into her life with a unique story of his own. Will the two of them be able to grow into their dreams together, or will their dreams be sidelined?

Max is a 25-year-old freelance writer and aspiring novelist who seems well on his way to success in London’s cultural spheres. Yet by night, he finds a different kind of exhilaration as a sex worker with the pseudonym Sebastian, meeting men via an escorting platform. Max uses his experiences as Sebastian to fuel his stories and the worthy debut novel that he has been longing to write, finally seems within reach.

Stevie, fresh from prison in Scotland, finds a job on a London construction site. The working conditions are poor and most of the men are working under aliases, due to immigration status and to not conflict with their "signing on" for unemployment benefits. Some coworkers help Stevie secure housing, squatting in a council estate. Then Stevie meets Susan, from Ireland, who's struggling to be a professional singer.

Nine years later, Jesse travels across Europe giving readings from a book he wrote about the night he spent in Vienna with Celine. After his reading in Paris, Celine finds him, and they spend part of the day together before Jesse has to again leave for a flight. They are both in relationships now, and Jesse has a son, but as their strong feelings for each other start to return, both confess a longing for more.

In 1965, a young woman with dreams of becoming a writer has a son at the age of 15 and struggles to make things work with the drug-addicted father.

A cranky, retired author reluctantly embarks on a final book tour to help out a young publisher.

Neil, a self-proclaimed film geek and owner of Gumshoe video, has always been content to live vicariously through his favorite films noir. But when he meets Violet, a real-life femme fatale, his mundane world gets turned upside down and the line between reality and the movies quickly begins to blur.

86-year-old Irving Zisman is on a journey across America with the most unlikely companion: his 8 year-old grandson, Billy.