Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.

An alcoholic drifter spends Halloween in his hometown of Albany, New York after returning there for the first time in decades.

Hotshot real estate salesman Daryl has a bad cocaine habit. After embezzling his company's money, he wakes up next to a girl who overdosed. To hide from the police, he checks into a rehabilitation program guaranteeing anonymity. Under the mentorship of counselor Craig, Daryl accepts that he has a substance abuse problem. As he falls in love with fellow patient Charlie, Daryl begins committing to a newly sober life.

John LeTour is a recovering drug user who suffers insomnia and still deals to a high-end New York clientele, even though he’s trying to move on from the business. John’s professional midlife crisis becomes something more acute — and dangerous — when he re-encounters an old flame while a string of seemingly drug-related murders rocks the city.

Juggling increasing career success and a growing heroin habit, a television comedy writer attempts to go down a path of improvement.

In 1973, when Frank Bledsoe and his 18-year-old niece Beth take a road trip from Manhattan to Creekville, South Carolina for the family patriarch's funeral, they're unexpectedly joined by Frank's lover Walid.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

A woman struggles to recover from a brutal attack by setting out on a mission for revenge.

Story about the remarkable friendship between a reclusive writer and illustrator and a chaotic homeless man, whom he gets to know during a campaign to release two charity workers from prison.

A headstrong young woman returns to New Orleans after the death of her estranged mother.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

The tender, heartbreaking story of a young man’s struggle to find himself, told across three defining chapters in his life as he experiences the ecstasy, pain, and beauty of falling in love, while grappling with his own sexuality.

Hannah and Tahir fall in love while homeless on the streets of New York. Shelter explores how they got there, and as we learn about their pasts we realize they need each other to build a future.

A young drug-addled writer approaching the bottom of his descent submits to two months of agonizing detox at a treatment center in Minnesota.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

Over the course of one night, a woman drives across LA with her heroin addict brother in search of a detox center, with his two-year-old daughter in tow.

When an innovative modern architect flees post-war Europe, he is given the opportunity to rebuild his legacy. Set during the dawn of the modern United States (in Pennsylvania), his wife joins him, and their lives are forever changed by a demanding, wealthy patron.

Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.

After suffering a brutal defeat and being told he can no longer fight, 37-year-old, scar-ridden prizefighter Louis 'Mountain' Rivera struggles to find a new direction in life.